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Me: how to characterize the difference or distance between two distribution configuration?

Bing: There are different ways to measure the difference or distance between two distribution configurations, depending on what aspects of the distributions you want to compare. Some common methods are:

There are many other methods, such as Wasserstein distance, Bhattacharyya distance, Jensen-Shannon divergence, etc. You can read more about them online or in textbooks on statistics or information theory.